先天的に気道の感受性が異なったモルモットの血圧値

桑原 正貴; 矢田 英昭; 矢来 幸弘; 秋田 恵; 戸田 典子; 菅野 茂; 西端 良治; 三上 博輝; 局 博一

doi:10.11276/jsvc.33.1

ORIGINALS

Arterial Blood Pressure in Guinea Pigs with Congenitally Different Airway Sensitivity

Masayoshi KUWAHARA, Hideaki YADA, Yukihiro YAGI, Megumi AKITA, Noriko TODA, Shigeru SUGANO, Ryoji NISHIBATA, Hiroki MIKAMI, Hirokazu TSUBONE

Author information

Masayoshi KUWAHARA
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hideaki YADA
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yukihiro YAGI
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Megumi AKITA
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Noriko TODA
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Shigeru SUGANO
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Ryoji NISHIBATA
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
Hiroki MIKAMI
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
Hirokazu TSUBONE
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Keywords: airway hyperresponsiveness, blood pressure, guinea pig

JOURNAL FREE ACCESS

2000 Volume 33 Issue 1 Pages 1-5

DOI https://doi.org/10.11276/jsvc.33.1

Details

Abstract

We investigated the characteristics of arterial blood pressures and heart rate (HR) in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs under conscious state. Arterial blood pressures (systolic blood pressure; SBP, mean blood pressure; MBP, diastolic blood pressure; DBP) were measured using a recently developed oscillometric device. The values of measurement parameters are as follows; BHS (HR: 253.5±5.1, SBP: 105.7±1.6, MBP: 75.1±1.9, DBP: 60.0±2.2) and BHR (HR: 253.7±4.2, SBP: 106.8±1.3, MBP: 72.7±1.6, DBP: 55.8±1.9). We could not observe any differences in arterial blood pressures and HR between these strains. These results suggest that airway hyperresponsiveness is not significantly affected on the cardiovascular functions under resting conditions.

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