The Effects of Subcutaneous ANP Administration in Normal Canine

Abstract

The objective of our investigation was to evaluate the effectiveness of subcutaneous atrial natriuretic peptide (ANP) administration in normal dogs. We administrated subcutaneously recombinant ANP (25 μg/kg). Plasma ANP concentration rapidly increased and peak concentration of 591.5±143.0 pg/ml reached at 5 min after subcutaneous ANP administration. Area under the blood concentration time curve was 27,874 min·pg/ml and elimination half time was 18.9±3.7 min. Systolic blood pressure was decreased and urine volume was increased. However, electrolyte excretion was not significant change. Our results suggest that subcutaneous ANP administration had biological effects in normal dogs.