Characterization of Morphological, Biochemical and Electrocardiological Assessments in Young Cardiomyopathic Hamsters

Hiroyuki ARAKAWA; Hiroshi KODAMA; Nobuya MATSUOKA; Isamu YAMAGUCHI

doi:10.11276/jsvc1984.30.74

Hiroyuki ARAKAWA, Hiroshi KODAMA, Nobuya MATSUOKA, Isamu YAMAGUCHI

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Keywords: Cardiomyopathic hamster, telemetry ECG, creatine phosphokinase

JOURNAL FREE ACCESS

1997 Volume 30 Issue 2 Pages 74-81

DOI https://doi.org/10.11276/jsvc1984.30.74

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Published: 1997 Received: - Available on J-STAGE: September 17, 2009 Accepted: November 04, 1997 Advance online publication: - Revised: -
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Date of correction: September 17, 2009 Reason for correction: - Correction: ABSTRACT Details: [in Japanese]

Date of correction: September 17, 2009 Reason for correction: - Correction: CITATION Details: Wrong : 3) Homberger, F (1979): Myopathy of hamster dystrophy : history and morphologic aspects. Ann. NY. Acad. Sci., 317, 2-17.
4) Tamura, N., Ogawa, Y., Itch, H., Arai, H., Suga, S., Nakagawa, O., Komatsu, Y., Kishimoto, I., Takaya, K., Yoshimasa, T., Shiono, S. and K. Nakao (1994): Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides. J. Clin. Invest., 94, 1059-68.
5) Khuchua, Z. A., Vasiljeva, E. V., Clark, J. F., Korchazkina, O. V., Branishte, T., Kapelko, V.I., Kuznetsov, A. V. and C. R. Ventura (1992): The creatine kinase system and cardiomyopathy. Am. J. Cardiovasc. Pathol., 4, 223-234.
6) Awad,S. S. and J. D. Welty (1990): Comparisons of hemodynamics throughout the life span of the BIO 14.6 cardiomyopathic with the FIB normal hamster. Comp. Biochem. Physiol., 97A, 487-491.
7) Nagano, M., Kato, M., Nagai, M. and J. Yang (1991): Protective effect of ACE-and kininase-inhibitor on the onset of cardiomyopathy. Basic Res. Cardiol., 86Suppl, 187-195.
8) Munakata, M., Imai, Y., Minami, N., Sasaki, S., Ichijyo, T., Yoshizawa, M., Sekino, H., Abe, K. and K. Yoshinaga (1990): Cosinor analysis of changes in circadian blood pressure rhythm with aging spontaneously hypertensive rats. Tohoku J. Exp. Med., 161, 55-64.
9) Sato, K., Chatani F. and S. Sato (1995): Circadian and short-term variabilities in blood pressure and heart rate measured by telemetry in rabbits and rats. J. Auton. Nerv. Syst., 54, 235-246.
10) Lemmer, B., Mattes, A., Bohm M and D. Ganten (1993): Circadian blood pressure variation in transgenic hypertensive rats. Hypertension, 22, 97-101.
11) Hano, O., Mitsuoka, T., Matsumoto, Y., Ahmed, R., Hirata, M., Hirata, T., Mori, M., Yano, K. and K. Hashiba (1991): Arrhythmogenic properties of the ventricular myocardium in cardiomyopathic Syrian hamster, BIO 14.6 strain. Cardiovasc. Res., 25, 49-57.
12) Takeda, A., Kawai, S., Okada, R., Nagai, M., Takeda, N. and M. Nagano (1993): Three-dimensional distribution of myocardial fibrosis in the new J-2-N cardiomyopathic hamsters : Comparison with electrocardiographic findings. Heart Vessels, 8, 186-193.
15) Kato, M., Takeda, N., Yang, J. and M. Nagano (1992): The effects of angiotensin converting enzyme inhibitors and the role of the renin-angtiotensin-aldosterone system in J-2-N cardiomyopathic hamsters. Join. Circ. J., 56, 46-51.
16) Yao, K. and A. Kurasawa (1994): Protective effects of benidipine against myocardial damage following ischemia and reperfusion in the isolated perfused rat heart. Biol. Pharm. Bull., 17, 517-521.
17) Bachmann, E. and E. Weber (1993): Recirculating, retrograde heart perfusion according to the Langendorff method for evaluation of MTG-methyl-2-tetradecylglycidate, McNeil3716- cardiomyopathy. Pharrnacol. Toxicol., 72, 98-106.
18) Cachofeiro, V., Schiffrin, E. L., Cantin, M. and R. Garcia (1990): Glomerular and vascular atrial natriuretic factor in cardiomyopathic hamsters : correlation with the peptide biological effects. Cardiovasc. Res., 24, 843-850.
19) Mukaddam, D.S., Jankowski, M., Dam, T.V., Quillen, E. W. and J. Gutkowska (1995): Renal atrial natriuretic factor receptors in hamster cardiomyopathy. Kidney. Int., 48, 1875-1885.
20) Luk, J. K., Wong, E. F. and N. L. Wong (1994) Second messenger changes of atrial natriuretic factor and brain natriuretic peptide in kidneys of cardiomyopathic hamsters. Cardiology., 85, 82-87.

Right : 3) Homberger, F (1979): Myopathy of hamster dystrophy : history and morphologic aspects. Ann. NY. Acad. Sci., 317, 2-17.
4) Tamura, N., Ogawa, Y., Itoh, H., Arai, H., Suga, S., Nakagawa, O., Komatsu, Y., Kishimoto, I., Takaya, K., Yoshimasa, T., Shiono, S. and K. Nakao (1994): Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides. J. Clin. Invest., 94, 1059-68.
5) Khuchua, Z. A., Vasiljeva, E. V., Clark, J. F., Korchazkina, O. V., Branishte, T., Kapelko, V.I., Kuznetsov, A. V. and C. R. Ventura (1992): The creatine kinase system and cardiomyopathy. Am. J. Cardiovasc. Pathol., 4, 223-234.
6) Awad,S. S. and J. D. Welty (1990): Comparisons of hemodynamics throughout the life span of the BIO 14.6 cardiomyopathic with the FIB normal hamster. Comp. Biochem. Physiol., 97A, 487-491.
7) Nagano, M., Kato, M., Nagai, M. and J. Yang (1991): Protective effect of ACE-and kininase-inhibitor on the onset of cardiomyopathy. Basic Res. Cardiol., 86Suppl, 187-195.
8) Munakata, M., Imai, Y., Minami, N., Sasaki, S., Ichijyo, T., Yoshizawa, M., Sekino, H., Abe, K. and K. Yoshinaga (1990): Cosinor analysis of changes in circadian blood pressure rhythm with aging spontaneously hypertensive rats. Tohoku J. Exp. Med., 161, 55-64.
9) Sato, K., Chatani F. and S. Sato (1995): Circadian and short-term variabilities in blood pressure and heart rate measured by telemetry in rabbits and rats. J. Auton. Nerv. Syst., 54, 235-246.
10) Lemmer, B., Mattes, A., Bohm M and D. Ganten (1993): Circadian blood pressure variation in transgenic hypertensive rats. Hypertension, 22, 97-101.
11) Hano, O., Mitsuoka, T., Matsumoto, Y., Ahmed, R., Hirata, M., Hirata, T., Mori, M., Yano, K. and K. Hashiba (1991): Arrhythmogenic properties of the ventricular myocardium in cardiomyopathic Syrian hamster, BIO 14.6 strain. Cardiovasc. Res., 25, 49-57.
12) Takeda, A., Kawai, S., Okada, R., Nagai, M., Takeda, N. and M. Nagano (1993): Three-dimensional distribution of myocardial fibrosis in the new J-2-N cardiomyopathic hamsters : Comparison with electrocardiographic findings. Heart Vessels, 8, 186-193.
15) Kato, M., Takeda, N., Yang, J. and M. Nagano (1992): The effects of angiotensin converting enzyme inhibitors and the role of the renin-angtiotensin-aldosterone system in J-2-N cardiomyopathic hamsters. Jpn. Circ. J., 56, 46-51.
16) Yao, K. and A. Kurasawa (1994): Protective effects of benidipine against myocardial damage following ischemia and reperfusion in the isolated perfused rat heart. Biol. Pharm. Bull., 17, 517-521.
17) Bachmann, E. and E. Weber (1993): Recirculating, retrograde heart perfusion according to the Langendorff method for evaluation of MTG-methyl-2-tetradecylglycidate, McNeil3716- cardiomyopathy. Pharrnacol. Toxicol., 72, 98-106.
18) Cachofeiro, V., Schiffrin, E. L., Cantin, M. and R. Garcia (1990): Glomerular and vascular atrial natriuretic factor in cardiomyopathic hamsters : correlation with the peptide biological effects. Cardiovasc. Res., 24, 843-850.
19) Mukaddam, D.S., Jankowski, M., Dam, T.V., Quillen, E. W. and J. Gutkowska (1995): Renal atrial natriuretic factor receptors in hamster cardiomyopathy. Kidney. Int., 48, 1875-1885.
20) Luk, J. K., Wong, E. F. and N. L. Wong (1994) Second messenger changes of atrial natriuretic factor and brain natriuretic peptide in kidneys of cardiomyopathic hamsters. Cardiology., 85, 82-87.

Abstract

The purpose of this study was to clarify the morphologic, biochemical and electrocardiographical character of young cardiomyopathic hamsters (BI014.6) compared with age-matched healthy hamsters (FIB). In the present study we report following ; (1) The relative weights of the heart and kidney were significantly increased in the cardiomyopathic hamsters compared with the healthy hamsters ; (2) Plasma levels of CPK, GOT, and GPT were significantly higher in the cardiomyopathic hamsters than in the healthy hamsters ; (3) There were no differences in ECG between the cardiomyopathic and healthy hamsters and also arrhythmias at the age of 2.5 months. The intervals of R-R and PQ were significantly shorter in the cardiomyopathic hamsters but the QT interval was significantly longer than in the healthy hamsters. These morphologic aspects and biochemical profiles indicated that the young cardiomyopathic hamsters exhibited a cardiac hypertrophy and disturbance in the heart muscle. However, from the electrophysiological viewpoint, it is probable that the cardiomyopathic hamsters have still managed to be normal at the age.

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