Four Cases of Refractory Leg Ulcers Associated with Klinefelter Syndrome

Abstract

Klinefelter syndrome is the most common major abnormality of sexual differentiation in men, with 2 or more X chromosomes. The occurrence of venous stasis leg ulcers is frequent in patient with Klinefelter syndrome, but it is often overlooked. However, Klinefelter syndrome must be considered in the differential diagnosis of patients with stasis dermatitis, refractory leg ulcers, but with no confirmed underlying disease. We report 4 cases of refractory leg ulcers complicated with Klinefelter syndrome over a period of 6 years from 2004.