Wound Management in Chronic Limb Threatening Ischemia (CLTI)

Abstract

Wound Bed Preparation (WBP) is a fundamental concept in the wound management of refractory ulcers. The basic concept of WBP is to remove these inhibitors (T: tissue non-viable of deficient, I: infection or inflammation, M: moisture imbalance and E: edge of wound-non advancing or undermined) and prepare the wound environment so that it is responsive to treatment. The TIME concept defines four factors (T, I, M, and E), and describes clinical interventions and their outcomes for each factor. The TIME concept is a theory that describes the clinical interventions for each factor and the results of those interventions. In the case of chronic limb threatening ischemia (CLTI), clinical intervention specific to CLTI is necessary, as clinical intervention based on the usual TIME theory alone not only delays healing but may also lead to major amputation.