水道水中の強力な変異原物質3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) の分布と毒性

杉山 千歳; 中嶋 圓; 岩本 憲人; 増田 修一; 大石 悦男; 木苗 直秀

doi:10.2965/jswe.27.393

Review Paper

Distribution of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in Water Samples, and Its Chemical and Genotoxic Properties

Chitose SUGIYAMA, Madoka NAKAJIMA, Ken-ichi IWAMOTO, Shuichi MASUDA, Etsuo OISHI, Naohide KINAE

Author information

Keywords: 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), drinking water, distribution, genotoxicity, risk assessment

JOURNAL FREE ACCESS

2004 Volume 27 Issue 6 Pages 393-401

DOI https://doi.org/10.2965/jswe.27.393

Details

Abstract

Various mutagens and carcinogens are formed during the chlorine disinfection of raw drinking water. Among them, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), exhibits a high mutagenic activity against Salmonella typhimurium TA100 without S9 mix, which is comparable to aflatoxin B₁. Recently, it has been demonstrated that MX induces stomach tumor to rats in the 2-stage carcinogenicity test using N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this review, we summarize the distribution of MX in several water samples including drinking water and its chemical, biological and genotoxic properties.

Corresponding author

Register with J-STAGE for free!