Abstract
The antidiabetic activity of Fuscoporia oblique (Fuscoporia Murr.) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Fuscoporia oblique (FO) (100 mg/kg body weight) improved hyperglycemia after an oral administration of fructose or maltose in KK-Ay mice. FO reduced the blood glucose of KK-Ay mice 4 hours after a single oral administration when compared with the control. FO reduced the blood glucose of KK-Ay mice 6 weeks after repeated administration, and also significantly decreased the plasma insulin of KK-Ay mice under similar conditions. However, FO did not affect the blood glucose in normal mice. FO tended to decrease the blood glucose in an insulin tolerance test. These results suggest that the antidiabetic activity of FO is derived, at least in part, from a decrease in plasma insulin, due to the decrease of insulin resistance.
