Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

Leena SUNTORNSUK; Keiichi KOIZUMI; Yurika SAITOH; Eliane Shizuka NAKAMURA; Naparat KAMMASUD; Opa VAJARAGUPTA; Ikuo SAIKI

doi:10.11339/jtm.21.94

Original

Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex

Leena SUNTORNSUK, Keiichi KOIZUMI, Yurika SAITOH, Eliane Shizuka NAKAMURA, Naparat KAMMASUD, Opa VAJARAGUPTA, Ikuo SAIKI

Author information

Leena SUNTORNSUK
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University
Keiichi KOIZUMI
Department of Bioscience, Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Yurika SAITOH
Department of Bioscience, Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Eliane Shizuka NAKAMURA
Department of Bioscience, Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Naparat KAMMASUD
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University
Opa VAJARAGUPTA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University
Ikuo SAIKI
Department of Bioscience, Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
21st Century COE Program,Toyama Medical and Pharmaceutical University

Keywords: angiogenesis, cancer, tube formation, curcumin, human umbilical vascular endothelial cell

JOURNAL FREE ACCESS

2004 Volume 21 Issue 2 Pages 94-99

DOI https://doi.org/10.11339/jtm.21.94

Details

Abstract

We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.

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