Abstract
The antidiabetic activity of Cissus sicyoides (Vitaceae) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Cissus sicyoides (CS) (500 mg/kg body weight) improved hyperglycemia after an oral administration of maltose in KK-Ay mice. CS significantly reduced maltase activity in small intestine of KK-Ay mice. CS reduced the blood glucose of KK-Ay mice 2 weeks after repeated administration without changing plasma insulin level. These results suggest that the antidiabetic activity of CS is derived, at least in part, due to the inhibition of maltase activity.
