Association of remnant-like lipoprotein particles cholesterol with "oketsu" syndrome

Yutaka TAKAYA; Takahiro SHINTANI; Eiichi TAHARA; Yasuyuki TSUKIOKA; Kenzo MORIYAMA; Kikuyo NAKAO; Hideaki MATSUDA; Atsushi NIIZAWA; Hiroyuki NINOMIYA; Hirozo GOTO; Yutaka SHIMADA; Katsutoshi TERASAWA

doi:10.11339/jtm.23.147

Regular Article

Association of remnant-like lipoprotein particles cholesterol with "oketsu" syndrome

Yutaka TAKAYA, Takahiro SHINTANI, Eiichi TAHARA, Yasuyuki TSUKIOKA, Kenzo MORIYAMA, Kikuyo NAKAO, Hideaki MATSUDA, Atsushi NIIZAWA, Hiroyuki NINOMIYA, Hirozo GOTO, Yutaka SHIMADA, Katsutoshi TERASAWA

Author information

Yutaka TAKAYA
Department of Internal Medicine, Meimai Central Hospital
Research Institute of Oriental Medicine, Kinki University
Takahiro SHINTANI
Research Institute of Oriental Medicine, Kinki University
Eiichi TAHARA
Research Institute of Oriental Medicine, Kinki University
Yasuyuki TSUKIOKA
Research Institute of Oriental Medicine, Kinki University
Kenzo MORIYAMA
Research Institute of Oriental Medicine, Kinki University
Kikuyo NAKAO
Research Institute of Oriental Medicine, Kinki University
Hideaki MATSUDA
Natural Drug Resources, School of Pharmaceutical Sciences, Kinki University
Atsushi NIIZAWA
Department of Japanese-Oriental Medicine, Kanebo Memorial Hospital
Hiroyuki NINOMIYA
Department of Japanese-Oriental Medicine, Kanebo Memorial Hospital
Hirozo GOTO
Department of Japanese-Oriental (Kamp) Medicine, Faculty of Medicine, University of Toyama
Yutaka SHIMADA
Department of Japanese-Oriental (Kamp) Medicine, Faculty of Medicine, University of Toyama
Katsutoshi TERASAWA
Department of Japanese-Oriental (Kampo) Medicine, Graduate School of Medicine, Chiba University

Keywords: Remnant-like lipoprotein particles cholesterol, "Oketsu" syndrome, Cardiovascular disease

JOURNAL FREE ACCESS

2006 Volume 23 Issue 4 Pages 147-150

DOI https://doi.org/10.11339/jtm.23.147

Details

Abstract

Increasing evidence suggests that remnant-like lipoprotein particles cholesterol (RLP-C) is an independent cardiovascular disease (CVD) risk factor. High levels of RLP-C exhibit findings similar to those of "oketsu" syndrome on blood rheology studies and scanning electron micrographs. We measured levels of RLP-C in plasma samples and "oketsu" scores obtained in 199 randomly selected subjects. The coefficient of correlation between levels of RLP-C and "oketsu" score was highly significant (r=0.581, P<0.0001). This finding suggests that presence of excess RLP-C in the blood resembles closely "oketsu" syndrome which we have shown to be an independent risk factor for CVD.

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