Abstract
Shakuyakukanzoto(SKT) consists of two kinds of crude drugs, Shakuyaku and Kanzo. SKT is used for leg cramps, stomachache, and menstrual colic pain. Clinically, different combination ratios of Shakuyaku and Kanzo exists, including the use of Kagenho (modified formulations) of an other Kampo formulation. But it remains un clear which ratio is best to apply.
We investigated the best combination ratio of Shakuyaku and Kanzo using mouse for the estimation of intestinal tract movement. SKT composed of Shakuyaku 50% and Kanzo 50% significantly decreased intestinal tract movement, comparable to atropin. These data suggest that these combination ratios of Shakuyaku and Kanzo work best for suppressing peristaltic motion.
In this study, we demonstrated that the combination ratio of Shakuyaku and Kanzo used as the formulation is reasonable from the standpoint of pharmacological background.
