Abstract
Chinese herbal medicine has historically been used for the treatment of renal disease. The clinical efficacy of Yozinkodakuto and its additional prescription was investigated in 28 patients (19 males and 9 females) with chronic renal failure (CRF). The underlying diseases for CRF were 14 cases of chronic glomerulonephritis, 8 cases of diabetic nephropathy, 2 cases of nephrosclerosis, 1 case of polycystic kidney, 1 case of gouty kidney, and 2 cases of unknown origin. Serum creatinine (Cr) concentrations were improved significantly with Yozinkodakuto at 6 months independent of the underlying disease. There were no remarkable changes in the levels of serum phosphorus, karium and uric acid between before and after treatment. Adverse effects were itching in 5 cases and stomatitis in 2 cases, but no major side effects were seen. This study suggests that Yozinkodakuto is a useful agent in the treatment of CRF.
