Abstract
Free radicals have been reported to participate in formation of gastric legions, and thus this scavenging action shows gastric lesion protective activity. It was known that Ginkgo biloba L. exhibits the effect of scavenging free radicals. In the present study, we attempted to isolate an active principle from Ginkgo biloba L.. Ginkgo biloba L. inhibited the formation of gastric lesions induced by ethanol, aspirin and indomethacin. An ethyl acetate and hexane layer of Ginkgo biloba L. gave sciadopitysin and 2-(12-heptadecenyl)-6-hydroxy-benzoic acid when separated by using the inhibitory activity on ethanol- induced gastric lesions in rats as an index. And these compounds had a positive effect on gastric lesion protection similarly to sucralfate.
