Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress

Abstract

The extract of Sasa kurilentis was found to strongly inhibit ascorbate/Fe²⁺-stimulated formation of thiobarbituric reactive substances, an indicator of lipid peroxidation, in isolated rat liver mitochondoria, and further to protect human embryonic lung (HEL) cells from H₂O₂-induced mitochondrial dysfunction in a dose-dependent manner. Moreover, the Sasa extract effectively prevented the intracellular ROS production in HUVEC exposed to the high concentration (30 mM) of glucose and also greatly inhibited the adhesion of U937 leukemia cells to HUVEC exposed to oxidative stress. Thus, the antioxidative benefits of the Sasa extract observed in the present study may contribute to improve endothelial dysfunction related to hyperglycemia.