Abstract
Mice were fed a diet supplemented with an ethanol extract of pig bile (PB), which resulted in the reduction of hepatic triglyceride (TG) content compared with the mice fed a control diet. The expression levels of mRNA of sterol regulatory element-binding protein-1c (Srebp-1c) and its target lipogenic enzymes including stearoyl-CoA desaturase 1 (Scd1) in liver were reduced by PB-supplemented diet compared with the control diet. Analysis of fatty acid composition in liver supported the attenuation of Scd1 activity in the liver by PB supplementation. This study demonstrates the TG-lowering effect of PB administration, in which the suppressions of lipogenesis and desaturation of saturated fatty acids in liver are suggested to play important roles.
