Mineral changes with age in bone of senescence accelerated mouse (SAM)

Abstract

The effect of aging on the mineral status in bone was studied using two strains (SAMP1 and SAMR1) of senescence accelerated mouse. Two month old, 6 month old and 10 month old female SAMP1 and SAMR1 mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, phosphorus, sulfur, sodium and potassium concentrations in tibia of the mice were determined. In SAMP1, the iron concentration of 2 month old mice was higher than that of older mice and a significant difference was detected between 2 and 6 month. In addition, the iron levels in SAMP1 were lower than those in SAMR1 at the respective age. The zinc concentration of SAMP1 was significantly increased with age. The zinc concentration of 2 month old mice of SAMP1 was significantly lower than that of SAMR1. In SAMR1, calcium, magnesium and phosphorus concentrations of 10 month old mice were lower compared with those of younger mice. The magnesium concentration of 2 month old mice was significantly higher than that of 10 month old. With respect to aging, the results on iron may reflect a decrease of bone marrow hemopoiesis in SAMP1.