Accumulation of selenium in tumor tissue of brain.

Abstract

Eighteen weaning male Wistar rats were produced glioma in brain and were divided into three groups, which received selenium (sodium selenite)0, 2, 5 ppm in drinking water. The accumulation and retention of selenium in brain bearing tumor was investigated. Significant higher concentrations of selenium were observed in tumor tissue than normal brain tissue after exposure to sodium selenite.The difference in selenium concentration between the tumor tissue and contralateral normal brain tissue was not influenced by the weight of body, and water consumption. We observed that selenium was accumulated in the tumor tissue more than in normal brain tissue.