The Relationship between the Movement of Trace Elements and Parathyroid Hormone (PTH) in the Zinc Deficiency-and Organotin- Induced Brain Lesion

Abstract

Deficiency and excess of trace elements induces various kind of brain lesion. In this study, to elucidate the relationship between the induction of brain lesion and trace elements in the brain, the movement of trace elements in various brain tissues was biochemically investigated under the symptom manifestation of disturbance of memory, learning defects and disturbance of olfactory acuity (anosmia) induced by zinc deficiency or organotin (tributyltin) exposure.

Remarkable results are that a) a zinc deficiency induced a significant accumulation of calcium into the olfactory and of aluminum into the hippocampus, b) organotin exposure induced a significant accumulation of calcium into the olfactory, c) these excessive accumulation of calcium and aluminum into the specified tissues were associated with an increase of parathyroid hormone (PTH) in the tissues.