1995 Volume 12 Pages 117-123
The effect of the different dietary magnesium or calcium level on magnesium behavior in mice were investigated. Forty eight ddy male mice were divided into 4 groups 1 to 4. Group 1 (magnesium 40mg/calcium 503mg in 100g diet) , group 2 (magnesium 40mg/calcium 965mg) , group 3 (magnesium 3mg/ calcium 459mg) , and group 4 (magnesium 3mg/ calcium 946mg) were maintained for 6 days by experimental diet. Biodistribution studies of double trace method with 28Mg and 45Ca, and whole body-macroradioluminography of 28Mg were performed in mice. The concentration of magnesium and calcium in liver, heart, kidney and bone were analyzed by 1 CPS-5000. The radioluminographs of a mouse fed the magnesium dificient diet (group 3, 4) revealed high accumulation of a 28Mg in heart and gut compared with the other groups. On the tissues biodistribution, 28Mg had a significantly high uptake in the heart, liver, and small intestine, low uptake in bone of group 3 with the other groups. The distribution of 45Ca were not changed between four groups. The magnesium concentration was significantly lower in liver and kidney of group 2, 3 and 4, in heart and bone of group 4 than in those of group 1. The calcium concentration was significantly lower in liver of group 2 than in these of group 1. The calcium concentration was significantly higher in heart of group 4 than in those of group 1. It was concluded from these results as follows : 1) Under magnesium deficiency, magnesium uptake in bone was decreased, but in the other organs (heart) were not changed so large in any calcium concentration. 2) The any ratio of calcium to magnesium (molar ratio ; 20~190) in this experimental diet did not affected on the magnesium transfer to organs.
