1996 Volume 13 Pages 129-134
In 1925, Matsuoka and Yoshimatsu reported about the new metabolite of Trp, which was named as kynurenin by Prof. Yashiro Kotake. And also the decomposed enzyme of kynurenin was named as kynureninase.
The Kynureninase is a B6 related enzyme, in which enzyme activity of the liver decreased in experimental DM rats.
In 1995, Takeuchi, Shibata et al. defined the primary structure of this enzyme protein, and its active center is similar to those of cystathionine synthase and lyase. Both decreased enzyme activity and diabetic conditions were recovered by taurine (intermedial metabolite of Met. or Cys) administration.
