Proceeding
Effect of Lateral Ventricular Injection of Zn on Food Intake in Rats Fed Zn-deficient Diet
1996 Volume 13 Pages 19-22
Details
1996 Volume 13 Pages 19-22
When rats are offered a zinc-deficient diet, they decrease their total food intake. Their normal food intake alternate with low intake in a 3-5 day cycle. The present study was conducted to examine the function of free zinc in the regulation of appetite in zinc-deficient rats.
Zero, 1. 5, 15 and 150 ppm-Zn as Zn (NO3)2 and 150 ppm-Zn as ZnSO4 dissolved in 10 μl of Ringer solution was injected into the lateral ventricle of zinc-deficient rats indicating low food intake. The central administration of Zn was once a day at 8:00 p.m. The daily food intake was measured during short (3 days) and long (8-11 days) period of the injection. Total food intake and the cyclic alternation of daily food intake in zinc-deficient rats were not recovered by the lateral-ventricular administration of inorganic Zn. The reduced food intake by dietary zinc insufficiency may not depend on the change of extracellular zinc concentration.
