Proceeding
Vanadium and Diabetes Mellitus
1999 Volume 16 Pages 1-12
Details
1999 Volume 16 Pages 1-12
Recent intensive research has demonstrated that vanadate (VO3-, oxidation state +5) and vanadyl (VO2+. oxidation state +4) both mimic almost various actions of insulin in cellular systems. An interest in vanadium emerged in 1985 that vanadate administrated orally as a drinking water to streptozotocin-induced heperglycemic diabetic rats (STZ-rats) reduced the high levels of blood glucose down to normal levels and ameliorated many of the aberrations induced by hyperglycemia. In 1990, we proposed first orally active vanadyl complexes such as vanadyl-cysteinemethylester and vanadyl-oxalate complexes in STZ-rats. Since then, we have developed orally active vanadyl complexes with different coordination modes such as VO(O4), VO(O2N2). VO(N4), VO(S4) and VO(S2N2). Among them, vanadyl-picolinatecomplexes with VO (N2N2) coordination mode have been found to be potent insulin-mimetic agents, on the basis of the results on in vitro test using isolated rat adipocytes with respect to the inhibition of the release of free fatty acids (FFA) from the cells and in vivo evaluation (intraperitoneal injection and oral administration) using STZ-rats. Based on the results, the usefulness of vanadyl in treating and preventing diabetes mellitus has been proposed.
References
1) H. Sakurai and A. Tsuji, in "Vanadium in the Environment" ed by J. 0. Nriagu, John Wiley & Sons, New York, 1998, 297
2) H. Sakurai, K. Fujii, S. Fujimoto, Y. Fujisawa, K. Takechi, and H. Yasui, in “Vanadium Compounds : Chemistry, Biochemistry, and Therapeutic Applications, ACS Sym. Ser. 711”ed by A. S. Tracey and D. C. Crans, ACS. Washington, 1998, 344
