Proceeding
Alterations in Lipid Metabolism in Rats Received the Nitric Oxide Donor, Sodium Nitroprusside (SNP)
1999 Volume 16 Pages 71-74
Details
1999 Volume 16 Pages 71-74
Recently, we have found that administration of the nitric oxide (NO) synthase inhibitor to rats caused hyperlipidemia and higher body fat, implying the fat accumulation by inhibiting NO synthesis in vivo. In this study, we investigated the alterations in lipid metabolism of rats received the NO donor, sodium nitroprusside (SNP). Rats were received SNP in drinking water at 0.03% for 5 weeks. The rats were fed the same amount of the high fat diet between the two groups. Growth was unaffected by SNP treatment. The weight of abdominal adipose tissue was reduced by SNP. Serum total cholesterol and free fatty acid were also reduced by SNP, while serum triglyceride was unaffected by SNP. The results suggest that higher NO is associated with lower body fat and serum cholesterol.
