Proceeding
Inhibitory Effect of 5・hydroxyanthranilicAcid on Urinary Bladder Carcinogenesis in Mice Treated with N-butyl-N-(4-hydroxybutyl) Nitrosamine
1985 Volume 2 Pages 119-125
Details
1985 Volume 2 Pages 119-125
The effect of tryptophan metabolites, anthranilic acid (A. A.) and 5-hydroxyanthranilic acid ( 5-OH-A.A) on urinary bladder carcinogenesis in mice treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were studied.
ICR strain male mice were divided into 6 groups and given following additions in drinking water for 20 weeks. To group 1, no chemical, group 2, 0.025% BBN, group 3, 0.025% BBN and A.A. (0.5mg/mouse/day), group 4, 0.025% BBN and 5-OH-A.A. (same dose), group 5, A.A. only, and group 6, 5-OH-A.A. only were added.
Carcinoma of the urinary bladder developed in 11 of 30 mice (group 2), 5 of 30 mice (group 3) and 3 of 30 mice (group 4). Mice drinken tap water (group 1), only A.A. (group 5) and only 5-OH-A.A. (group 6) had no lesion of the urinary bladder except for occasional hyperplasia.
These result show that A.A. and 5-OH-A.A. inhibit the urinary bladder carcinogenesis in mice induced by BBN.
