Effects of dietary water-soluble rice bran, phytic acid and myo-inositol on prevention of fatty liver in rats fed DDT.

Abstract

We have previously shown that dietary myo-inositol and phytic acid similarly depressed the increases in hepatic lipids and lipogenic enzymes activities in rats fed 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). The present study was conducted to investigate whether dietary water-soluble rice bran, which contains 27.8% phytic acid, would also have an anti-fatty liver function. As well as dietary 1.02% sodium phytate and the equimolor myo-inositol (0.2%), dietary 1.7% water-soluble rice bran, which contains the similar level of phytic acid to 1.02% sodium phytate, generally reduced the hepatic lipids and lipogenic enzymes activities. They enhanced the rises in hepatic activity of phase II drug-metabolizing enzyme, glutathione S-transferase, in rats fed DDT. On the other hand, dietary water-soluble rice bran reduced hepatic cytochrome P-450 content, while dietary phytic acid and myo-inositol had no effect on it in rats fed DDT. The present study suggests that dietary water-soluble rice bran, in addition to the functions of phytic acid, has additional functions.