2006 Volume 23 Pages 13-16
During the past twenty years, many studies have been conducted to evaluate the effect of oyster extract on various life-style related diseases. The present study was designed to evaluate the preventive effects of oyster extract on the formation of chemically induced colonic aberrant crypt foci (ACF). At 6 weeks of age, mice fed an AIN93G modified diet containing oyster extract (0.2, 1.0 and 5.0 %) were given DMH (25 mg/kg body wt) once weekly for 6weeks. The number of ACF was evaluated in the 0.1 % methylene blue stained colon. ACF was scored under a light microscope with 40 times magnification to transluminate the colon. ACF were distinguished from normal crypts by their large size and elliptical shape. The mice fed the oyster extract diet showed decreased colonic total ACF and with a multiplicity of 4+ aberrant crypts compared with control. It is considered that the intake of oyster extract caused effectively detoxication of DMH because a few decrease rate of body weight and mortality. As feeding dosage of oyster extract, the development of ACF was inhibited effectively. Further, ACF multiplication more than 4+ aberrant crypts was inhibited. These results suggest that dietary oyster extract showed promise in colon cancer prevention by reducing the ACF formation. However, clear evidence of cancer prevention was not obtained in the present study.
