Effect of Dietary Molybdenum Level on Tissue and Serum Molybdenum Concentrations in Rats

Abstract

Molybdenum status was examined in rats fed experimental diets containing graded level of molybdenum. Male 5-week Wistar rats were divided into three groups. One group was fed a basal AIN93G diet without ammonium molybdate (molybdenum content, 0.08 μg/g) and other groups were fed the basal diet supplemented with 0.1 or 0.5 μg/g of molybdenum as ammonium molybdate for 4 weeks. Molybdenum concentrations in liver and kidney of the rats were not varied with dietary molybdenum intake level but the serum molybdenum concentration was gradually increased with an increase of dietary molybdenum level. Dietary molybdenum level did not effect on copper concentrations in the liver, kidney and serum as well as xanthine oxidase activity in the liver and the serum uric acid level. These results indicate that variation of dietary molybdenum level in the present study (0.08 to 0.58 μg/g) did not effect on molybdenum status other than serum molybdenum concentration.