2010 Volume 27 Pages 35-38
We designed to examine the effect of kudzu vine extracts (PVEE) on bone resorption and bone organization in ovariectomized mice. The uterine of all OVX mice was atrophic. Oral administration of PVEE did not affect the uterine size of OVX mice. A bone resorption marker (Deoxypyridinoline) was significantly increased by OVX, and the increase was effectively suppressed by administration of PVEE for 2 weeks. The femoral bone mineral density (BMD) of OVX mice with CT analysis was significantly restored by the administration of PVEE. These results clearly demonstrated that PVEE improved effectively the postmenopausal bone loss in ovariectomized mice, and kudzu vine might be a promising food resource preventing osteoporosis.
