Effects of Bochu, Shachu, and Suishitsu Extracts on Human Platelets Aggregation

Abstract

The inhibitory effects of the extracts from anti-"Oketsu"drugs, Bochu, Shachu, and Suishitsu on the aggregation of human platelets were examined.

1) Hot water extracts of BochU, Shachu, and Suishitsu inhibited the aggregation of human platelets induced by adenosine diphosphate (ADP) and epinephrine.

2) Fraction 2 separated from ShachU extract using Sephadex G-50 showed the remarkable inhibition of platelet aggregation by ADP.

3) Fraction 1 (high molecular fraction of sugar) separated from Suishitsu extract using Sephadex G-50 inhibited remarkably the platelet aggregation by ADP.