1992 Volume 9 Pages 67-73
Ohta et al. reported that oyster (Crassostrea gigas) extract (O.E) inhibited the platelet aggregation in alloxan diabetic rats and this action was caused by the nucleic acid-related substances (N.A.). Furthermore, influence of some mimerals on the platelet aggregation was also reported that Zinc (Zn) and Magnesium (Mg) inhibited the platelet aggregation, but Calcium (Ca) accelerated. In this study, the changes of the platelet aggregation, the nucleotides in whole blood and the minerals in serum have been investigated in O.E. administered diabetes mellitus (D.M.) patients.
4 tablets of O.E. (containing 270 mg O.E. powder/1 tablet) were orally administered to subjects every day for 7 months. Zn, Mg, Ca in serum, N.A. in whole blood and platelet aggregation were determined in healthy adults (n = 7), insulin-dependent diabetes mellitus (IDDM) (n = 4)and non-insulin-dependent diabetes mellitus (NIDDM) (n = 4). Platelet aggregation of 8 subjects among 15 subjects was improved after continuous administration of O.E. for 1 month. In this period, the significant increase of AMP ratio [i.e. AMP/(AMP+ADP+ATP+Adenosine)]was observed in all subjects. However, ADP ratio [i.e. ADP/(AMP+ADP+ATP+Adenosine)]was significantly decerased in healthy subjects. In D.M. patients, ADP ratio tended to be decreased. About the serum minerals, serum Mg and Zn were decreased but Ca level was not changed m experimental period. In IDDM group, serum Zn was remarkably decreased compared with other groups. Effect of nucleotides on rat platelet aggregation was reported previously, but these findings suggested that some of nucleotides were related to the suppressive effect on human platelet aggregation. And oyster extract tablets might be available for the improvement of diabetes mellitus.
