Abstract
Immunosuppressive effects in dogs after operation and anesthesia were investigated through the change in immunological activity of neutrophils, macrophages and peripheral blood lymphocytes (PBL) by chemiluminescence (CL) . In anesthesia group, changes in CL activity were minimal. In operation group, the increase in neurophil count and CL activity of whole blood (neurophils) was observed one day after operation. Reductions in macrophages and PBL activities were observed immediately after operation. However after these changes neutrophils activity reduced and macrophages and PBL activities increased to make peaks at 72 hr postoperation, respectively. These results suggest that immunological activities of these white blood cells contribute on defence mechanism in surgically stressed animals.
