A Case of Application of BMP to Infections Atrophic Nonunion Fracture of Canine Metatarsals

Abstract

An 8-year-old male Shetland sheepdog (11.5 kg) was referred to the Hokkaido University Veterinary Teaching Hospital 28 days after the initial repair of metatarsal fractures with bone plating and wiring. But fractures developed an infectious atrophic nonunion 125 days after the referral. Plate fixation and rhBMP-2 implantation were done in an attempt to correct this condition. rhBMP-2 was implanted with a PGS carrier, which was synthetic polymer and gelatin sponge complex. Metatarsal ossifications were radiographically present by 25 days, and all fractures revealed healing 63 days after the implantation of rhBMP-2. rhBMP-2 may be useful to promote and accelerate bone ossification for nonunion fractures in dogs.