Amlodipine induced hepatic enzyme elevation following mitral valve repair in a dog

Abstract

An 11-year-old, hound mixed breed dog weighing 18.5 kg was diagnosed with mitral valve insufficiency in private veterinary hospital in France. The dog was referred for mitral valve repair surgery at JASMINE Veterinary Cardiovascular Medical Center. After mitral valve repair, severe hepatic enzyme elevation was observed during the hospitalization period. Those hepatic enzyme elevation were suspected the cause of hepatitis by postoperative drug side effects or thromboembolism were suspected. The side effect of amlodipine could have contributed to the increase in hepatic enzymes that concluded by diagnostic tests. Amlodipine was discontinued immediately and initiated symptomatic treatments, and then the hepatic enzymes have returned to normal range, with no relapse of hepatitis.