Partition Coefficients of Benzene Derivatives in Aqueous Two-Phase Systems Containing Polyethylene Glycol

Abstract

The liquid-liquid equilibria of the aqueous two-phase systems consisting of polyethylene glycol (M_w=7, 500) (1) -dipotassium hydrogenphosphate (2) -water (3), polyethylene glycol (1) -ammonium sulfate (2) -water (3) and polyethylene glycol (1) -dextran (M_w=515, 000, M_n =195, 300) (2) -water (3) were measured at 25°C. The partition coefficients of 15 benzene derivatives in these aqueous two-phase systems were also determined at 25°C.
Further, the osmotic virial equation was used to correlate the liquid-liquid equilibria of the aqueous two-phase systems and the partition coefficients of 15 benzene derivatives. An estimation of the partition coefficients was attempted by using molecular connectivity indices.