Abstract
It is possible to control a reaction rate in solution by adding rate enhancing solvent (solvent 2) such as a dipolar aprotic solvent to the feed which consists of reactant and solvent 1.
The addition of rate enhancing solvent increases reaction rate constant and it decreases inevitably the concentration of reactant in the reaction system. There may be, therefore, the optimum addition ratio of solvent 2 to the feed.
A graphical method to determine the optimum addition ratio of the solvent 2 was presented and was applied to saponification of ethyl benzoate and Hofmann reaction of bromo-benzamide in aqueous dimethyl sulfoxide and to hydrolysis of benzoyl chloride in aqueous acetone.
