2025 Volume 76 Issue 1 Pages 12-19
Hot flashes decrease the quality of life and increase the risk of cardiovascular diseases, but there are no established therapies for them. In this report, we describe two cases of hot flashes after hematopoietic stem cell transplantation successfully treated with jiinkokato. Case 1 was a 61-year-old woman with acute myeloid leukemia. She received cord blood transplantation and suffered from hot flashes, hyperhidrosis, and night sweat during tapering of immunosuppressants. She started to take jiinkokato and her symptoms improved immediately. Case 2 was a 51-year-old man with myelodysplastic syndrome. He received bone marrow transplantation, and developed hot flashes during taking bakumondoto and goshajinkigan for dry cough and dysuria. He switched from these Kampo medicines to jiinkokato and his symptoms improved gradually. In both cases the patients had conditions of the pattern of yin deficiency with excessive heat caused by strong cancer chemotherapy, so we considered jiinkokato to be effective for their hot flushes. We believe that jiinkokato may be an option for the treatment of hot flushes associated with hematopoietic stem cell transplantation.
