Invasive Haemophilus influenzae Type f Disease Caused by a β-Lactamase-Negative Ampicillin-Resistant Strain in a 5-Year-Old Child

Abstract

With the introduction of Haemophilus influenzae type b (Hib) conjugate vaccine, while the incidence of invasive Hib disease has decreased dramatically, cases of invasive H. influenzae disease (IHD) caused by nontypeable and non-type b strains continue to be seen. As compared to the incidence of IHD in the United States and European countries, the incidence of IHD among children, especially that of IHD caused by nontype b strains, is quite low in Japan. Infections by highly resistant and multiple-resistant H. influenzae are issues of global concern.