Studies on the Treatment of Japanese B Encephalitis (IV) Treatment with PANS-Preparations (2)

Abstract

Up to this time, we treated severe Japanese B encephalitis patients with PANS-25 in 1951, PANS-326 in 1952 and PANS-610 in 1953. Of these PANS-preparations, only one, PANS-610, proved to be clinically effective, but it was associated with considerable side effects, as thrombophlebitic symptoms and hematuria due to its hemolytic action.
In 1954, we treated encephalitis patients with PANS-610 AN and AS, which were newly prepared by Ueda and Toyoshima, and expected to have less side effects. The new PANS-preparations could not, however, display so distinct an effect upon some of the important symptoms, such as the disturbance of consciousness, fever, convulsion, as PANS-610. Side effects were almost the same with that of PANS-610 in some cases. In spite of these rather unsatisfactory clinical impressions, statistical analysis of the total results revealed a more favourable effects of these medicaments than that of PANS-610. The sequela rate was reduced and the rate of complete recovery increased, as shown in table 3.