1955 Volume 29 Issue 9 Pages 440-446
Since the Clinical application of electrophoresis by the Tiselius method there have been reported many papers on the correlation between the erythrocyte sedimentation rate (ESR) and the plasma protein fraction but the rerults differ according to the disease and according to the author even in the same disease and it is difficult to find a distsinct cause and effect relation between the two. This is a very interesting fact, and there exists a big question as to whether one can regard the correlation between the E.S.R. and the plasma protein fraction as being, without exception, and independent correlation and at the same time it is considered that it is a subject which can not be disregarded from the point of the analysis of the accelerating factor of the E.S.R. From this viewpoint the author and his coordinators are studying the accelerating foctor of the ESR. in various diseases. This time the author studied this in scarlatina.
In scarlatina it is characteristie for the E.S.R. to be comparatively ecclerated and simultaneausly for the γ-Globulin to be comparatively increased in the latter half of the course of the disease, In this report the simple correlation between the ESR. and the plasma protein fraction was studied stackustically. As a result in scarlatina those showing a significant relation with the ESR. with a significant level of 1% were albumin (negative) α-Globulin and fibrinogen (positiv). In regard to the three factors showing a correlation stackustically in this way, a question arises whether all three are always the real accelerating factor of the ESR. or oue of the three is the real accelerating fector and the other two the apparent factors. But in regard to this it is necessary to make a further study on the relation between fractions and morever a study be made by a partial correiation, a report will be made on this later. On the contrary, in regard to the β-Globulin and γ-Globulin which showed no correlation with the ESR. a study of the fluctuation of the dispersion of the respective measured value. It is considered that in this case the dispersion of both the β-Globnlin and γ-Globulin showed a large fluctuation can make one conclude that both fractions are factors distinctly showing no correlation whatsoever to the ESR.
