Peroral Infection of Japanese B Encephalitis.

Abstract

By peroral inoculation of JBE virus to hamsters the infection was established. Virus given perorally got to the central nerves and caused scuh histological changes as were !noticed when it was inoculated into the brains, similar histologic changes being observed also in the spinal cord.
Virus evoked cellular infiltration in the epithelium of the intestine just like polio virus.
JBE virus given perorally was excreted in stool for 3 or 4 days. The virus multiplied in the epithelium of intestine and then partly entered into the lymph stream, the mesenterial lymph nodules and thoracal duct and finally into blood circulation, and partly entered into portal vein, liver, v. hepatica and finally into general blood circulation, giving thusise to viremia.