Pharmacological Study of Candida Polysaccharide on Cardiovascular

System of Non-Immunized and Immunized Rats

Abstract

We investigated the activity of Candida albicans polysaccharide on the cardiovascular system of rats, and following results were obtained.
1) The heart: On Langendoriff's preparation of non-immunized rats, Candida polysaccharide increased left intraventriclar pressure (LIVP) and coronary flow (CE), and raised the heart rate (HR) after a temporary decrease.
The responses were dose-dependent. From these results, it is concluded that the Candida polysaccharide has cardiotonic and coronary vasodilatatory activities.
In the case of the immunized rats, Candida polysaccharide decreased LIVP and CF after a temporary increase and increased HR after a temporary decrease at the first challenge, but these preparations showed similar reactions in the heart of non-immunized animals at the second challenge.
This phenomen suggests that some chemical substance i.e. autacoids may be produced immunologically as seen in the Type I allergy by the IgE antibody.
The aorta: On spiral preparation of descending thracic aorta of non-immunized rats, Candida polysaccharide slightly constricted the aorta in the resting state and relased the aorta which was constricted phenylephrine. The responses were dose-dependent. As for the aorta of immunized rats, Candida polysaccharide increased only the constriction of the aorta in the resting state at the first challenge, but these preparations showed similar reactions in the non-immunized aorta at the second challenge. From these results, it is concluded that Candida polysaccharide has the vasoconstrictive activity and neutralizes the activity of phenylephrine.