A Case of Cytomegalovirus Mononucleosis in a Previously Healthy Adult

Abstract

A 20 year old woman was admitted to our hospital because of fatigue and persistent low grade fever lasting for a 8 month period.
Physical examination on admission revealed neither elevation of temperature, lymphadenopathy nor jaundice.
Laboratory studies showed increased leukocyte counts with absolute lymphocytosis including atypical lymphocytes, an elevation of GOT, GPT and LDH levels in the serum, a negative heterophil agglutination test and mild hepato-splenomegaly on the radiological scintigram. Anti-cytomegalovirus antibody of IgM class (ELISA) was markedly elevated, while antibodies against hepatitis associated antigen and EB-virus were negative.
Histological findings on liver biopsy showed sinusoidal infiltration of mononuclear cells, however, typical inclusions of cytomegalovirus were not identified.
Cytomegalovirus was isolated from urine specimens.