The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Third Department of Internal Medicine, Hirosaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Hokkaido University, School of Medicine and Related Hospitals
Department of Respiratory Diseases, Sapporo Hospital, Hokkaido Railway Company
Department of Respiratory Diseases, Sapporo Hospital, Hokkaido Railway Company
Department of Respiratory Diseases, Sapporo Hospital, Hokkaido Railway Company
The Second Department of Internal Medicine, Hiraka General Hospital
The Second Department of Internal Medicine, Hiraka General Hospital
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
The Third Department of Internal Medicine, Iwate Medical School and Related Hospitals
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
Department of Respiratory Diseases, Iwate Prefectural Central Hospital
The First Department of Internal Medicine, Yamagata University, School of Medicine
The First Department of Internal Medicine, Yamagata University, School of Medicine
The First Department of Internal Medicine, Yamagata University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
The First Department of Internal Medicine, Tohoku University, School of Medicine
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
Department of Respiratory Diseases, Iwaki Kyoritsu General Hospital
Department of Respiratory Diseases, Iwaki Kyoritsu General Hospital
Department of Internal Medicine, Kasumigaura National Hospital Department of Pulmonary Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital Department of Pulmonary Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital Department of Pulmonary Medicine, Kasumigaura National Hospital
Department of Internal Medicine, Kasumigaura National Hospital Department of Pulmonary Medicine, Kasumigaura National Hospital
The Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School
The Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School
The Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School
Department of Internal Medicine, School of Medicine, Keio University
Department of Internal Medicine, School of Medicine, Keio University
Department of Internal Medicine, Tokyo Denryoku Hospital
Department of Internal Medicine, Tokyo Denryoku Hospital
The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, The Jikei University School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
The Second Department of Internal Medicine, Teikyo University, School of Medicine
Department of Internal Medicine, Teikyo University, School of Medicine, Ichihara Hospital
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
The First Department of Internal Medicine, Kyorin University, School of Medicine
Department of Infectious Disease, Institute of Medical Sciense, University of Tokyo and Related Hospital
Department of Infectious Disease, Institute of Medical Sciense, University of Tokyo and Related Hospital
Department of Infectious Disease, Institute of Medical Sciense, University of Tokyo and Related Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Respiratory Disease, Toranomon Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Koseinenkin Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Tokyo Kyosai Hospital
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Juntendo University, School of Medicine
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
Department of Internal Medicine, Kawasaki Municipal Hospital
The First Department of Internal Medicine, Yokohama City University, School of Medicine
The First Department of Internal Medicine, Yokohama City University, School of Medicine
Department of Internal Medicine, Yokohama Teishin Hospital
Department of Internal Medicine, Kanagawa Prefectural Nursing and Hygienic School Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
Department of Respiratory Diseases, Kanagawa Prefectural Nagahama Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
The Second Department of Internal Medicine, Niigata University, School of Medicine and Related Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Shinrakuen Hospital
Department of Internal Medicine, Toyama Prefectural Central Hospital
Division of Respiratory Disease, Department of Internal Medicine, Kanazawa Medical University
Division of Respiratory Disease, Department of Internal Medicine, Kanazawa Medical University
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospitals
The First Department of Internal Medicine, Nagoya City University, School of Medicine and Related Hospitals
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Department of Internal Medicine, Tane General Hospital
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
The Third Department of Internal Medicine, Tottori University, School of Medicine
The Third Department of Internal Medicine, Tottori University, School of Medicine
The Third Department of Internal Medicine, Tottori University, School of Medicine
The Third Department of Internal Medicine, Tottori University, School of Medicine
The Third Department of Internal Medicine, Tottori University, School of Medicine
The Second Department of Internal Medicine, Hiroshima University, School of Medicine
The Second Department of Internal Medicine, Hiroshima University, School of Medicine
The Second Department of Internal Medicine, Hiroshima University, School of Medicine
The Second Department of Internal Medicine, Hiroshima University, School of Medicine
The Second Department of Internal Medicine, Hiroshima University, School of Medicine
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
Department of Internal Medicine, Kure National Hospital
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
The Second Department of Internal Medicine, Nagasaki University, School of Medicine and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospitals
The First Department of Internal Medicine, Kumamoto University, Medical School
The First Department of Internal Medicine, Kumamoto University, Medical School
The First Department of Internal Medicine, Kumamoto University, Medical School
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
The Second Department of Internal Medicine, Medical College of Oita
Department of Internal Medicine, Tokyo Women's Medical College
1989 Volume 63 Issue 4 Pages 318-351
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The clinical efficacy and safety of Cefodizime (CDZM), a new cephem antibiotic, was objectively compared with that of Cefotaxime (CTX) in patients with respiratory infections under a wellcontrolled comparative study.
Patients were administered CDZM or CTX by drip infusion b. i. d. for 14 days in principle at a daily dose of two grams.
The parameters assessed were clinical efficacy, icacy, safety and clinical usefulness.
The following results were obtained:
1. On the basis of committee judgement the clinical efficacy rate was 78.1%(125/160) for the CDZM group, 82.7%(124/150) for the CTX group, and no significant difference was observed between the two drug groups. On the other hand, on the basisofjudgement by physicians in charge, the clinical efficacy rate was 83.1%(133/160) for the CDZM group, 83.9%(125/149) for the CTX group, and no significant difference was observed between the two groups.
2. The corresponding figures for patients with pneumonia and pulmonary suppuration were 82.4%(70/85) for the CDZM group, 79.7%(59/74) for the CTX group and no significant difference was observed according to the committee judgement. The judgement by physicians in charge also revealed 83.5%(71/85) for the CDZM group and 82.2%(60/73) for the CTX group. No.significant difference was noted between the two groups. While, the committee judgement for the clinical efficacy in patients with chronic respiratory tract infections showed 73.3%(55/75) for the CDZM group, 85.5%(65/76) for the CTX group, and no significant difference was observed between the two drug groups. The corresponding figures were 82.7%(62/75) for the CDZM group, 85.5%(65/76) for the CTX group, and no significant difference was observed between the two drug groups on the judgement by physicians in charge.
Furthermore, the clinical efficacy of both drugs on chronic respiratory tract infections was assessed according to “Criteria for Evaluation of Clinical Efficacy of Chemotherapeutics on Chronic Respiratory Tract Infection”. It was 76.8%(53/69) for the CDZM group, 76.3%(58/76) for the CTX group, and no significant difference was observed between the two groups.
3. The bacteriological eradication rate of causative pathogens was 92.4% out of 66 patients treated with CDZM and 95.5% out of 67 patients treated with CTX in whom judgement was possible. No significant difference was observed between the two drug groups.
4. The adverse reactions occurred in 4 (2.2%) patients for the CDZM group and 8 (4.5%) patients for the CTX group respectively, with no significant inter-group difference in frequency of these reactions for all cases. But the adverse reactions classified by pneumonia and pulmonary suppuration occurred in no patients for the CDZM group and 4 (5.1%) for the CTX group, with significantly less incidence in the former than the latter (p<0.05). The abnormal changes in laboratory findings were observed in 26.6%(45/169) for the CDZM group and 24.1%(39/162) for the CTX group, with no significant difference between the two groups for all cases.
5. There was no significant difference in the utility between the two groups for all cases, pneumonia, pulmonary suppuration and chronic respiratory tract infection groups according to both the commitee judgement and physicians' one.
Thus, it was concluded that CDZM is a drug with clinically high usefulness by the overall assessment on the basis of clinical efficacy and safety.