Successful Treatment for Active Cytomegalovirus Infection by Cytomegalovirus Antibody-Enriched Immunoglobulin in a Renal Transplant Recipient

Abstract

Active cytomegalovirus (CMV) infection was treated successfully by only CMV antibodyenriched immunoglobulin (CMV-IG) in a renal transplant recipient. CMV-IG was injected at 86 mg/kg iv twice a day for a total of 16 days (4 plus 12 days, interrupted by a pause of 4 days), followed by weekly iv injection of 86 mg/kg (7 weeks). Active CMV infection was diagnosed on the basis of DNAemia in plasma, by a newly developed CMV polymerase chain reaction (PCR) test (AMPLICOR ^® CMV). The disappearance of CMV from plasma was confirmed by this PCR test. It seems that single CMV-IG therapy is worth consideration for the treatment of CMV infection