A case of severe autoimmune hepatitis triggered by discontining long term Celestamine^® treatment

Abstract

The patient was a 70-year-old man. He had been treated with Celestamine^® about three years for his chronic sinusitis. He was admitted to our hospital for his clinical symptoms including nausea, pruritus, and yellow urine. We diagnosed autoimmune hepatitis from the examinations and clinical course. At first, we treated him with UDCA (600mg/day). His general condition was not well for several days, so we then treated him with PSL (30mg/day), where upon he improved. The pathological findings showed inflammation cell permeation and rosette formation. It was thought that his discontinuation of Celestamine^® triggered deterioration resulting in serious autoimmune hepatitis. Moreover, much remains unclear as to the implications of the excess iron deposits in liver tissue in terms of autoimmune hepatitis. Thus, further investigations are necessary in this regard.