Abstract
Here, I reported the case of a family cluster of hepatitis B virus infection; this family was followed up and treated for a long period. Four male siblings of the 7 siblings developed hepatocellular carcinoma (HCC). The eldest son in the family (second child), died from HCC at the age of 46; the second son (fourth child) died from alcoholic hepatic insufficiency at the age of 47, a year after successful hepatic resection for HCC. The third son (fifth child) underwent hepatic resection for HCC at the age of 75; the fourth son (seventh child) developed HCC at the age of 61, and he was treated with radiofrequency thermal ablation and a nucleotide analog. The third and fourth sons are alive and clinically healthy without HCC recurrence. However, the remaining 3 siblings, i.e., the female siblings, did not develop HCC. Among them, the first (first child) and third (sixth child) daughters are alive and disease free at he age of 92 and 70, respectively, but the second daughter (third child) died of stomach cancer at the age of 82.
Factors related to HCC high occurrence in these 4 brothers were discussed in focus with sex, alcohol consumption, smoking habit, diabetes and body mass index through a review of related literature. Further, the clinical course and treatment history of the fourth son (seventh child) was reported.
