A case of hepatocellular carcinoma arising from chronic hepatitis B caused by HBV genotype Ae and NASH without perisinusoidal fibrosis

Abstract

A 70-year-old Japanese man underwent posterior segmentectomy of liver in order to treat hepatocellular carcinoma occurred after 2 years follow-up for presumed inactive carrier of hepatitis B virus with complication of nonalcoholic fatty liver disease. Depending upon precise histological assessment for underlying liver disease using the sample obtained by surgery, pathological diagnosis both chronic hepatitis B and nonalcoholic steatohepatitis (NASH) with grade 1 and stage 0 were confirmed. The current report is the first one in which minute clinical, virological and pathological characteristics are described for hepatocellular carcinoma developed in mild chronic hepatitis B caused by HBV genotype Ae and NASH with no fibrosis.