A case of drug-induced pneumonitis caused by transcatheter arterial infusion with miriplatin for hepatocellular carcinoma

Abstract

A 69 year-old man was admitted to our hospital for purpose of transcatheter arterial infusion (TAI) with miriplatin for advanced hepatocellular carcinoma. Eight days after TAI, cough and sputum developed. Seventeen days after TAI, dyspnea with marked hypoxemia and diffuse ground-glass opacities in bilateral lung fields were revealed by a chest CT scan. We started use of mechanical ventilation and high dose corticosteroid therapy for acute respiratory failure. Gradually, his respiratory condition improved, and 24 days after TAI, he was werning from respirator. As a cause of the pneumonitis, infectious diseases were ruled out by serodiagnosis, sputum culture and bronchoalveolar lavage. We clinically diagnosed drug-induced pneumonitis caused by TAI with miriplatin.