急性肝不全に対する血液浄化療法の有効性評価：急性肝不全に対する人工肝補助療法の現状に関するアンケート調査報告

藤原 慶一; 横須賀 收; 織田 成人; 荒田 慎寿; 井上 和明; 滝川 康裕; 井戸 章雄; 持田 智; 坪内 博仁; 「難治性の肝・胆道疾患に関する調査研究」班 劇症肝炎分科会 血液浄化法の有効性評価を目的としたワーキンググループ

doi:10.2957/kanzo.53.530

Short Communications

Present status of artificial liver support for acute liver failure in Japan

Keiichi Fujiwara, Osamu Yokosuka, Shigeto Oda, Shinju Arata, Kazuaki Inoue, Yasuhiro Takikawa, Akio Ido, Satoshi Mochida, Hirohito Tsubouchi, the Intractable Hepato-Biliary Disease Study Group of Japan

Author information

Keiichi Fujiwara
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University
Osamu Yokosuka
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University
Shigeto Oda
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University
Shinju Arata
Yokohama City University School of Medicine
Kazuaki Inoue
Division of Gastroenterology, Showa University Fujigaoka Hospital
Yasuhiro Takikawa
Department of Gastroenterology and Hepatology, Iwate Medical University
Akio Ido
Department of Digestive and Lifestyle Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences
Satoshi Mochida
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Saitama Medical University
Hirohito Tsubouchi
Department of Digestive and Lifestyle Related Disease, Health Research Course, Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences
the Intractable Hepato-Biliary Disease Study Group of Japan
The Ministry of Health, Labor and Welfare of Japan

Keywords: acute liver failure, artificial liver support, on-line hemodiafiltration

JOURNAL FREE ACCESS

2012 Volume 53 Issue 8 Pages 530-533

DOI https://doi.org/10.2957/kanzo.53.530

Details

Abstract

We examined the present status of artificial liver support (ALS) for acute liver failure (ALF) in Japan, by sending the questionnaires about the number of ALF cases, the methods of ALS and the recovery rate of consciousness. ALS comprising plasma exchange and hemodiafiltration (HDF) has been performed in more than 80% of 125 hospitals, but high flow volume HDF (high flow continuous HDF or on-line HDF) in 23 hospitals only. Totally, 50% of patients with fulminant hepatitis and late-onset hepatic failure achieved restoration of consciousness, which was lower than that reported by high flow volume HDF. On-line HDF which reduces the cost and simplifies the procedure is expected to be the main ALS in patients with ALF in the future.

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