2015 Volume 56 Issue 10 Pages 526-532
An 82-year-old man with a liver tumor was referred and admitted to our hospital for further examination. Enhanced computed tomography revealed a hypovascular liver tumor with left portal vein invasion. Magnetic resonance cholangiopancreatography demonstrated stenosis of the left hepatic duct and dilatation of the peripheral intrahepatic bile ducts within the tumor. Histological evidence of neuroendocrine tumor (grade 3) was obtained by using percutaneous tumor biopsy. 18F-Fluorodeoxyglucose positron emission tomography and endoscopic investigations were performed to exclude the presence of extrahepatic lesions, and a diagnosis of primary hepatic neuroendocrine tumor was established. Five months after hepatectomy, the patient died of multiple intrahepatic recurrences. The bile duct findings within the resected tumor led us to speculate that the pathogenesis of the primary hepatic neuroendocrine tumor was a transformation of the neuroendocrine cells from the left bile duct.
